Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 11/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.52 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | P2RY12 | Q9H244 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29826538 | 1.00 | PRKDC (0.54) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL24713625 | 0.90 | PRKDC (0.53) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL24713569 | 0.87 | PRKDC (0.52) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL29826321 | 0.86 | PIK3CA (0.50) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL29160434 | 0.86 | PIK3CA (0.50) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL24713841 | 0.86 | PIK3CA (0.50) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL24713563 | 0.85 | PIK3CB (0.60) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL29826521 | 0.84 | PRKDC (0.41) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL24713942 | 0.84 | PRKDC (0.41) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL12666449 | 0.84 | PRKDC (0.55) | PRKDCPIK3CBPIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117615763-A | Phosphoinositide 3 kinase beta inhibitor, composition and preparation method thereof | 健道生物医药有限公司 | 2024-02-27 | — | — | CN | disclosed |
| WO-2022164812-A1 | PHOSPHOINOSITIDE 3 KINASE BETA INHIBITORS AND COMPOSITIONS AND METHODS THEREOF | GEODE THERAPEUTICS INC. (US) | 2022-08-04 | — | — | WO | disclosed |