Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.62 |
| ▸ | MET | P08581 | 3/20 | 0.62 |
| ▸ | AXL | P30530 | 4/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
| ▸ | NEK2 | P51955 | 1/20 | 0.51 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.51 |
| ▸ | INSR | P06213 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716377 | 0.90 | ALK (0.60) | ALKMETAXLCDK7CDK9 | |
| SCHEMBL24716309 | 0.89 | ALK (0.58) | ALKAXLNEK2MAP4K1 | |
| SCHEMBL24716360 | 0.88 | ALK (0.73) | ALKMETINSRKCNH2 | |
| SCHEMBL24716365 | 0.88 | AXL (0.73) | ALKAXLNEK2MAP4K1INSR | |
| SCHEMBL29869267 | 0.86 | ALK (0.60) | ALKMETAXLCDK7CDK9 | |
| SCHEMBL24716366 | 0.86 | ALK (0.60) | ALKMETAXLCDK7CDK9 | |
| SCHEMBL24716393 | 0.85 | ALK (0.55) | ALKAXLNEK2MAP4K1 | |
| SCHEMBL24716911 | 0.84 | ALK (0.62) | ALKMETAXLCDK7NEK2 | |
| SCHEMBL24716047 | 0.83 | MAP4K1 (0.54) | ALKMETAXLCDK9MAP4K1 | |
| SCHEMBL24716908 | 0.83 | MAP4K1 (0.53) | ALKMETAXLCDK9MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116848103-A | High activity HPK1 kinase inhibitors | 杭州阿诺生物医药科技有限公司 | 2023-10-03 | — | — | CN | disclosed |
| WO-2022214008-A1 | HIGHLY ACTIVE HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |