Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.58 |
| ▸ | AXL | P30530 | 4/20 | 0.58 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.55 |
| ▸ | NEK2 | P51955 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716377 | 0.92 | ALK (0.60) | ALKAXLMAP4K1NEK2AURKA | |
| SCHEMBL24716393 | 0.91 | ALK (0.55) | ALKAXLMAP4K1NEK2AURKA | |
| SCHEMBL24716036 | 0.89 | MAP4K1 (0.53) | ALKAXLMAP4K1 | |
| SCHEMBL24716365 | 0.89 | AXL (0.73) | ALKAXLMAP4K1NEK2AURKA | |
| SCHEMBL24716360 | 0.89 | ALK (0.73) | ALK | |
| SCHEMBL24716012 | 0.89 | ALK (0.62) | ALKAXLMAP4K1NEK2 | |
| SCHEMBL24716032 | 0.88 | MAP4K1 (0.51) | ALKAXLMAP4K1 | |
| SCHEMBL24716297 | 0.85 | ALK (0.57) | ALKAXLMAP4K1NEK2AURKA | |
| SCHEMBL29869266 | 0.85 | ALK (0.57) | ALKAXLMAP4K1NEK2AURKA | |
| SCHEMBL24716307 | 0.85 | MAP4K1 (0.55) | ALKAXLMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116848103-A | High activity HPK1 kinase inhibitors | 杭州阿诺生物医药科技有限公司 | 2023-10-03 | — | — | CN | disclosed |
| WO-2022214008-A1 | HIGHLY ACTIVE HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |