Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.58 |
| ▸ | AXL | P30530 | 4/20 | 0.58 |
| ▸ | INSR | P06213 | 2/20 | 0.54 |
| ▸ | IGF1R | P08069 | 2/20 | 0.54 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.51 |
| ▸ | NEK2 | P51955 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716297 | 0.92 | ALK (0.57) | ALKAXLMAP4K1NEK2AURKA | |
| SCHEMBL29869266 | 0.92 | ALK (0.57) | ALKAXLMAP4K1NEK2AURKA | |
| SCHEMBL24716293 | 0.91 | ALK (0.71) | ALKINSRMET | |
| SCHEMBL29869922 | 0.91 | ALK (0.71) | ALKINSRMET | |
| SCHEMBL24716362 | 0.91 | AXL (0.71) | ALKAXLINSRIGF1RMAP4K1 | |
| SCHEMBL29869267 | 0.91 | ALK (0.60) | ALKAXLINSRIGF1RMAP4K1 | |
| SCHEMBL24716366 | 0.91 | ALK (0.60) | ALKAXLINSRIGF1RMAP4K1 | |
| SCHEMBL24715919 | 0.87 | MAP4K1 (0.53) | ALKAXLMAP4K1MET | |
| SCHEMBL24716363 | 0.87 | MAP4K1 (0.61) | ALKAXLMAP4K1MET | |
| SCHEMBL29102658 | 0.86 | MAP4K1 (0.52) | ALKAXLMAP4K1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116848103-A | High activity HPK1 kinase inhibitors | 杭州阿诺生物医药科技有限公司 | 2023-10-03 | — | — | CN | disclosed |
| WO-2022214008-A1 | HIGHLY ACTIVE HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |