Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 7/20 | 0.71 |
| ▸ | NEK2 | P51955 | 1/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.56 |
| ▸ | INSR | P06213 | 4/20 | 0.55 |
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716029 | 0.91 | ALK (0.58) | AXLNEK2AURKAAURKBALK | |
| SCHEMBL24716297 | 0.90 | ALK (0.57) | AXLNEK2AURKAAURKBALK | |
| SCHEMBL29869266 | 0.90 | ALK (0.57) | AXLNEK2AURKAAURKBALK | |
| SCHEMBL24716293 | 0.89 | ALK (0.71) | ALKINSR | |
| SCHEMBL29869922 | 0.89 | ALK (0.71) | ALKINSR | |
| SCHEMBL29869267 | 0.88 | ALK (0.60) | AXLNEK2ALKINSRIGF1R | |
| SCHEMBL24716366 | 0.88 | ALK (0.60) | AXLNEK2ALKINSRIGF1R | |
| SCHEMBL24716365 | 0.86 | AXL (0.73) | AXLNEK2AURKAAURKBALK | |
| SCHEMBL24716363 | 0.85 | MAP4K1 (0.61) | AXLALKMAP4K1 | |
| SCHEMBL24715919 | 0.85 | MAP4K1 (0.53) | AXLALKMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022214008-A1 | HIGHLY ACTIVE HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |