Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 15/20 | 0.68 |
| ▸ | INSR | P06213 | 5/20 | 0.58 |
| ▸ | IGF1R | P08069 | 5/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | CD74 | P04233 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | FES | P07332 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24715916 | 0.94 | MAP4K1 (0.71) | MAP4K1INSRIGF1RALKCHEK1 | |
| SCHEMBL24716031 | 0.88 | MAP4K1 (0.71) | MAP4K1INSRIGF1RALKEGFR | |
| SCHEMBL24715910 | 0.86 | MAP4K1 (0.68) | MAP4K1INSRIGF1RALKEGFR | |
| SCHEMBL24716364 | 0.84 | MAP4K1 (0.68) | MAP4K1INSRIGF1RALK | |
| SCHEMBL24715921 | 0.84 | MAP4K1 (0.72) | MAP4K1INSRIGF1RALKEGFR | |
| SCHEMBL24715912 | 0.83 | MAP4K1 (0.72) | MAP4K1INSRIGF1RALKEGFR | |
| SCHEMBL20214787 | 0.82 | MAP4K1 (0.84) | MAP4K1INSRIGF1RALKEGFR | |
| SCHEMBL24039985 | 0.82 | MAP4K1 (0.84) | MAP4K1INSRIGF1RALKEGFR | |
| SCHEMBL24040082 | 0.81 | MAP4K1 (1.00) | MAP4K1INSRIGF1RALK | |
| SCHEMBL20214415 | 0.81 | MAP4K1 (1.00) | MAP4K1INSRIGF1RALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022214008-A1 | HIGHLY ACTIVE HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |