Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | METAP2 | P50579 | 2/20 | 0.62 |
| ▸ | METAP1 | P53582 | 2/20 | 0.62 |
| ▸ | BRD4 | O60885 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.56 |
| ▸ | MMP14 | P50281 | 3/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10624931 | 0.85 | KDM4E (0.66) | KDM4EHSP90AA1MAPTLMNAMETAP2 | |
| SCHEMBL24715867 | 0.82 | KDM4E (0.59) | KDM4EHSP90AA1MAPTLMNAMETAP2 | |
| SCHEMBL24715770 | 0.82 | HTT (0.59) | KDM4EHSP90AA1MAPTLMNAMETAP2 | |
| SCHEMBL24716661 | 0.82 | KDM4E (0.59) | KDM4EHSP90AA1MAPTLMNAMETAP2 | |
| Cloxyquin SCHEMBL4291941 | 0.79 | KDM4E (0.96) | KDM4EHSP90AA1MAPTLMNAMETAP2 | |
| Cloxyquin SCHEMBL29381298 | 0.77 | KDM4E (1.00) | KDM4EHSP90AA1MAPTLMNAMETAP2 | |
| Cloxyquin SCHEMBL115838 | 0.77 | KDM4E (1.00) | KDM4EHSP90AA1MAPTLMNAMETAP2 | |
| SCHEMBL3387174 | 0.76 | KDM4E (0.51) | KDM4EHSP90AA1MAPTLMNAMETAP2 | |
| SCHEMBL25287835 | 0.76 | MAPT (0.58) | KDM4EHSP90AA1MAPTLMNAMETAP2 | |
| Cloxyquin SCHEMBL4977328 | 0.76 | KDM4E (0.96) | KDM4EHSP90AA1MAPTLMNAMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120035438-A | Use of 8-hydroxyquinoline derivatives | 江苏亚虹医药科技股份有限公司 | 2025-05-23 | — | — | CN | disclosed |
| CN-118679149-A | 7-Cyano-8-hydroxyquinoline derivative, preparation method and medical application thereof | 江苏亚虹医药科技股份有限公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-118059101-A | Use of 8-hydroxyquinoline derivatives | 江苏亚虹医药科技股份有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-117186002-A | 7-cyano-8-hydroxyquinoline derivative, preparation method and medical application thereof | 江苏亚虹医药科技股份有限公司 | 2023-12-08 | — | — | CN | disclosed |
| WO-2023232019-A1 | 7-CYANO-8-HYDROXYQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 江苏亚虹医药科技股份有限公司 | 2023-12-07 | — | — | WO | disclosed |
| CN-117043141-A | 7-nitro-8-hydroxyquinoline derivative, preparation method and medical application thereof | 江苏亚虹医药科技股份有限公司 | 2023-11-10 | — | — | CN | disclosed |
| WO-2022253152-A1 | 7-NITRO-8-HYDROXYQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 江苏亚虹医药科技股份有限公司 | 2022-12-08 | — | — | WO | disclosed |