Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 11/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.52 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 2/20 | 0.47 |
| ▸ | INSR | P06213 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716302 | 0.87 | MAP4K1 (0.54) | MAP4K1ALKMETINSRIGF1R | |
| SCHEMBL24716906 | 0.84 | MAP4K1 (0.76) | MAP4K1ALKROS1METINSR | |
| SCHEMBL24716296 | 0.84 | MAP4K1 (0.53) | MAP4K1ALKMAP3K7 | |
| SCHEMBL24716046 | 0.82 | MAP4K1 (0.52) | MAP4K1ALKMET | |
| SCHEMBL24716375 | 0.82 | MAP4K1 (0.62) | MAP4K1ALKMETINSRIGF1R | |
| SCHEMBL24716911 | 0.81 | ALK (0.62) | MAP4K1ALKROS1METINSR | |
| SCHEMBL24716028 | 0.81 | MAP4K1 (0.51) | MAP4K1ALKMET | |
| SCHEMBL24394218 | 0.81 | TTK (0.41) | MAP4K1ALK | |
| SCHEMBL25339375 | 0.77 | MAP4K1 (0.61) | MAP4K1ALKROS1METINSR | |
| SCHEMBL30570439 | 0.77 | MAP3K14 (0.44) | MAP4K1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022214008-A1 | HIGHLY ACTIVE HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |