Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 13/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.52 |
| ▸ | INSR | P06213 | 5/20 | 0.52 |
| ▸ | IGF1R | P08069 | 5/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | STK10 | O94804 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | CD74 | P04233 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | FES | P07332 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716906 | 0.89 | MAP4K1 (0.76) | MAP4K1ALKINSRIGF1REGFR | |
| SCHEMBL25340442 | 0.87 | MAP4K1 (0.80) | MAP4K1ALK | |
| SCHEMBL30446890 | 0.84 | MAP4K1 (0.58) | MAP4K1ALKINSRIGF1REGFR | |
| SCHEMBL25338484 | 0.84 | MAP4K1 (0.64) | MAP4K1ALKEGFR | |
| SCHEMBL25338017 | 0.84 | MAP4K1 (0.65) | MAP4K1ALKINSRIGF1REGFR | |
| SCHEMBL25947729 | 0.83 | MAP4K1 (0.57) | MAP4K1ALKINSRIGF1REGFR | |
| SCHEMBL25337544 | 0.78 | MAP4K1 (0.65) | MAP4K1ALK | |
| SCHEMBL25339133 | 0.77 | MAP4K1 (0.64) | MAP4K1ALKINSRIGF1REGFR | |
| SCHEMBL24716294 | 0.77 | MAP4K1 (0.54) | MAP4K1ALKINSRIGF1RMET | |
| SCHEMBL24716375 | 0.76 | MAP4K1 (0.62) | MAP4K1ALKINSRIGF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227483-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | GLENMARK SPECIALITY S.A. (CH) | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227483-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | MAP4K1, MAP3K4, MAP4K2 | MAP4K1 1/4885ALK 2067/4885INSR 3399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.