Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 11/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716047 | 0.92 | MAP4K1 (0.54) | MAP4K1ALKAXLMETCCNK | |
| SCHEMBL24716037 | 0.91 | MAP4K1 (0.51) | MAP4K1ALKAXLMAP3K7MET | |
| SCHEMBL24715909 | 0.89 | MAP4K1 (0.53) | MAP4K1ALKAXLMAP3K7MET | |
| SCHEMBL24716912 | 0.89 | AXL (0.52) | MAP4K1ALKAXLMETCCNK | |
| SCHEMBL24716378 | 0.89 | MAP4K1 (0.53) | MAP4K1ALKAXLMETCCNK | |
| SCHEMBL24716027 | 0.85 | MAP4K1 (0.54) | MAP4K1ALKAXLMAP3K7MET | |
| SCHEMBL24716309 | 0.85 | ALK (0.58) | MAP4K1ALKAXL | |
| SCHEMBL24716054 | 0.84 | MAP4K1 (0.49) | MAP4K1 | |
| SCHEMBL24716908 | 0.84 | MAP4K1 (0.53) | MAP4K1ALKAXLMAP3K7MET | |
| SCHEMBL24716310 | 0.84 | MAP4K1 (0.54) | MAP4K1ALKAXLMAP3K7MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022214008-A1 | HIGHLY ACTIVE HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |