Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 10/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.48 |
| ▸ | AXL | P30530 | 3/20 | 0.47 |
| ▸ | CCNK | O75909 | 3/20 | 0.45 |
| ▸ | CCND3 | P30281 | 3/20 | 0.45 |
| ▸ | CDK9 | P50750 | 3/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716034 | 0.94 | MAP4K1 (0.51) | MAP4K1ALKAXLMET | |
| SCHEMBL24716297 | 0.88 | ALK (0.57) | MAP4K1ALKAXL | |
| SCHEMBL29869266 | 0.88 | ALK (0.57) | MAP4K1ALKAXL | |
| SCHEMBL24716032 | 0.86 | MAP4K1 (0.51) | MAP4K1ALKAXLCCNKCCND3 | |
| SCHEMBL24716363 | 0.85 | MAP4K1 (0.61) | MAP4K1ALKAXLMET | |
| SCHEMBL24716029 | 0.83 | ALK (0.58) | MAP4K1ALKAXLCDK9MET | |
| SCHEMBL24715922 | 0.83 | MAP4K1 (0.62) | MAP4K1ALKMET | |
| SCHEMBL24716366 | 0.82 | ALK (0.60) | MAP4K1ALKAXLCDK9MET | |
| SCHEMBL29869267 | 0.82 | ALK (0.60) | MAP4K1ALKAXLCDK9MET | |
| SCHEMBL24716027 | 0.82 | MAP4K1 (0.54) | MAP4K1ALKAXLMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022214008-A1 | HIGHLY ACTIVE HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |