Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.56 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.56 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2763564 | 0.78 | KDM4E (0.64) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL4296651 | 0.78 | KDM4E (0.60) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL13746159 | 0.78 | BRD4 (0.37) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL24718931 | 0.78 | BRD4 (0.53) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL14927151 | 0.78 | BRD4 (0.58) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| Bromide SCHEMBL1188167 | 0.77 | KDM4E (0.62) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL2362190 | 0.74 | ALDH1A1 (0.64) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL1188236 | 0.74 | PDE10A (0.35) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL12878973 | 0.74 | KDM4E (0.38) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL10806414 | 0.72 | KDM4E (0.65) | BRD4ADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253188-A1 | NITROGEN-CONTAINING FUSED HETEROAROMATIC BICYCLIC COMPOUNDS AS USP1 INHIBITORS AND THE USE THEREOF | IMPACT THERAPEUTICS (SHANGHAI) , INC (CN) | 2022-12-08 | — | — | WO | disclosed |