Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24719112 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL24718657 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL24718379 | 0.89 | POLB (0.45) | SMN1; SMN2ALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL24719109 | 0.87 | MEN1 (0.47) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL24718430 | 0.85 | P2RX1 (0.45) | SMN1; SMN2ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL24718823 | 0.85 | P2RX1 (0.45) | SMN1; SMN2ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL24718283 | 0.84 | MEN1 (0.45) | SMN1; SMN2ALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL24718400 | 0.83 | MEN1 (0.51) | ALDH1A1MEN1KMT2AMCHR1NPC1 | |
| SCHEMBL24718390 | 0.81 | MEN1 (0.50) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL24718656 | 0.80 | MEN1 (0.43) | SMN1; SMN2KDM4ELMNAPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220363633-A1 | SUBSTITUTED PYRROLIDONES AND PIPERIDONES AS SMALL MOLECULE INHIBITORS OF EZH2 AND EED PROTEIN BINDING | UNITED STATES GOVERNMENT | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220363633-A1 | SUBSTITUTED PYRROLIDONES AND PIPERIDONES AS SMALL MOLECULE INHIBITORS OF EZH2 AND EED PROTEIN BINDING | EED, EZH2, ELP1 | SMN1; SMN2 3120/4885ALDH1A1 1312/4885KDM4E 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.