Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTPRG | P23470 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24719109 | 0.90 | MEN1 (0.47) | MEN1KMT2AALDH1A1GAASIGMAR1 | |
| SCHEMBL24718422 | 0.83 | MEN1 (0.55) | MEN1KMT2AALDH1A1GAASIGMAR1 | |
| SCHEMBL24718657 | 0.81 | SMN1; SMN2 (0.44) | MEN1KMT2AALDH1A1GAALMNA | |
| SCHEMBL24719112 | 0.81 | SMN1; SMN2 (0.44) | MEN1KMT2AALDH1A1GAALMNA | |
| SCHEMBL24719133 | 0.81 | SMN1; SMN2 (0.44) | MEN1KMT2AALDH1A1GAALMNA | |
| SCHEMBL24718400 | 0.80 | MEN1 (0.51) | MEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL24718379 | 0.79 | POLB (0.45) | ALDH1A1GAALMNAMAPTPOLB | |
| SCHEMBL24719124 | 0.79 | MEN1 (0.50) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL24718644 | 0.77 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1GAAPOLB | |
| SCHEMBL24718827 | 0.75 | TP53 (0.49) | MEN1KMT2AALDH1A1GAASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220363633-A1 | SUBSTITUTED PYRROLIDONES AND PIPERIDONES AS SMALL MOLECULE INHIBITORS OF EZH2 AND EED PROTEIN BINDING | UNITED STATES GOVERNMENT | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220363633-A1 | SUBSTITUTED PYRROLIDONES AND PIPERIDONES AS SMALL MOLECULE INHIBITORS OF EZH2 AND EED PROTEIN BINDING | EED, EZH2, ELP1 | MEN1 3534/4885KMT2A 180/4885ALDH1A1 1312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.