Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL809036 | 1.00 | MAPT (0.36) | MAPTKCNA5ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL6367938 | 0.81 | — | — | |
| SCHEMBL7396087 | 0.76 | MAPT (0.35) | MAPTALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL109412 | 0.74 | FDPS (0.32) | KCNA5SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL13351477 | 0.73 | USP2 (0.38) | MAPTKCNA5ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL13319168 | 0.73 | SLC6A2 (0.34) | MAPTALDH1A1KMT2ALMNAHPGD | |
| SCHEMBL13319167 | 0.73 | MAPT (0.35) | MAPTKCNA5ALDH1A1KMT2ALMNA | |
| SCHEMBL7977214 | 0.73 | MAPT (0.41) | MAPTALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL21954031 | 0.73 | HRH3 (0.38) | MAPTKCNA5ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL57306 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022166920-A1 | PYRROLOPYRIDAZINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2022-08-11 | — | — | WO | disclosed |