Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 6/20 | 0.48 |
| ▸ | MMP2 | P08253 | 6/20 | 0.48 |
| ▸ | MMP9 | P14780 | 6/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26636136 | 0.81 | HTT (0.54) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL20445244 | 0.77 | ALDH1A1 (0.42) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL29060766 | 0.77 | HDAC2 (0.76) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL4029206 | 0.77 | HDAC2 (0.76) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL7663174 | 0.76 | HDAC3 (0.63) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL7656834 | 0.76 | HDAC2 (0.63) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL28440927 | 0.75 | HDAC2 (0.73) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL28440928 | 0.75 | HDAC2 (0.73) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL24292340 | 0.75 | HDAC8 (0.45) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL19403907 | 0.75 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2KMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324805-A1 | DRUG-INDUCED ACTIVATION OF THE REELIN SIGNALING SYSTEM | UNIVERSITY OF SOUTH FLORIDA | 2022-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220324805-A1 | DRUG-INDUCED ACTIVATION OF THE REELIN SIGNALING SYSTEM | LDLR, LRP6, PSEN2 | HDAC3 946/4885HDAC4 2623/4885HDAC1 1721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.