Sugi Predict

Sugi Predict / Compounds / SCHEMBL24724201

SCHEMBL24724201

SCHEMBL24724201

COC(=O)c1ccc(C(C)Br)cn1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 2/20 0.57
▸ KDM4E B2RXH2 2/20 0.46
▸ L3MBTL1 Q9Y468 1/20 0.46
▸ LCK P06239 1/20 0.40
▸ PARP1 P09874 1/20 0.40
▸ HRH3 Q9Y5N1 1/20 0.39
▸ MAPT P10636 3/20 0.38
▸ GABRP O00591 2/20 0.38
▸ GABRD O14764 2/20 0.38
▸ GABRA1 P14867 2/20 0.38
▸ GABRB1 P18505 2/20 0.38
▸ GABRG2 P18507 2/20 0.38
▸ GABRB3 P28472 2/20 0.38
▸ GABRA5 P31644 2/20 0.38
▸ GABRA3 P34903 2/20 0.38
▸ GABRA2 P47869 2/20 0.38
▸ GABRB2 P47870 2/20 0.38
▸ GABRA4 P48169 2/20 0.38
▸ GABRE P78334 2/20 0.38
▸ GABRA6 Q16445 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30827493 1.00 MAPK1 (0.57) MAPK1KDM4EL3MBTL1LCKPARP1
SCHEMBL9372497 0.88 MAPK1 (0.59) MAPK1KDM4EL3MBTL1LCKPARP1
SCHEMBL7882554 0.86 MAPK1 (0.61) MAPK1KDM4EL3MBTL1LCKPARP1
SCHEMBL31036563 0.85 MAPK1 (0.59) MAPK1KDM4EL3MBTL1LCKPARP1
SCHEMBL987417 0.85 MAPK1 (0.59) MAPK1KDM4EL3MBTL1LCKPARP1
SCHEMBL18489381 0.85 MAPK1 (0.59) MAPK1KDM4EL3MBTL1LCKPARP1
SCHEMBL29695096 0.83 MAPK1 (0.57) MAPK1KDM4EL3MBTL1LCKPARP1
SCHEMBL18758445 0.83 MAPK1 (0.57) MAPK1KDM4EL3MBTL1LCKPARP1
SCHEMBL29108186 0.83 MAPK1 (0.57) MAPK1KDM4EL3MBTL1LCKPARP1
SCHEMBL12583886 0.83 MAPK1 (0.57) MAPK1KDM4EL3MBTL1LCKPARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240287070-A1 FUSED HETEROCYCLIC DERIVATIVES JOHNSON & JOHNSON (CHINA) INVESTMENT LTD. (CN) 2024-08-29 — — US disclosed
US-20240279227-A1 FUSED HETEROCYCLIC DERIVATIVES JANSSEN BIOTECH, INC. 2024-08-22 — — US disclosed
CN-117881661-A Condensed heterocyclic derivative 杨森科学爱尔兰无限公司 2024-04-12 — — CN disclosed
CN-117715909-A Condensed heterocyclic derivative 杨森科学爱尔兰无限公司 2024-03-15 — — CN disclosed
WO-2022253259-A1 FUSED HETEROCYCLIC DERIVATIVES Janssen Sciences Ireland Unlimited Company (IE) 2022-12-08 — — WO disclosed
WO-2022253255-A1 FUSED HETEROCYCLIC DERIVATIVES Janssen Sciences Ireland Unlimited Company (IE) 2022-12-08 — — WO disclosed
CN-103717573-B Amido-pyridyl ether compounds and compositions and their use against parasites MERIAL, INC. (US) 2016-02-24 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240287070-A1 FUSED HETEROCYCLIC DERIVATIVES HAVCR2, HCCS, GOT2 MAPK1 4056/4885KDM4E 3515/4885L3MBTL1 4523/4885
US-20240279227-A1 FUSED HETEROCYCLIC DERIVATIVES HAVCR2, HCCS, GOT2 MAPK1 4056/4885KDM4E 3515/4885L3MBTL1 4523/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.