Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24724667 | 0.77 | CYP2D6 (0.46) | CYP2D6CYP2C19ALDH1A1CHRM2ADRA2A | |
| SCHEMBL1225311 | 0.75 | CYP2D6 (0.47) | CYP2D6CYP2C19TAAR1ALDH1A1CHRM2 | |
| SCHEMBL13338372 | 0.71 | CYP2D6 (0.47) | CYP2D6CYP2C19TAAR1ALDH1A1CHRM2 | |
| SCHEMBL15785637 | 0.71 | CYP2D6 (0.41) | CYP2D6CYP2C19ALDH1A1CHRM2ADRA2A | |
| SCHEMBL22786989 | 0.70 | CYP2D6 (0.40) | CYP2D6CYP2C19TAAR1ALDH1A1CHRM2 | |
| SCHEMBL85721 | 0.70 | CYP2D6 (0.55) | CYP2D6CYP2C19TAAR1ALDH1A1CHRM2 | |
| SCHEMBL15785686 | 0.69 | CYP2D6 (0.39) | CYP2D6CYP2C19ALDH1A1CHRM2ADRA2A | |
| SCHEMBL13180333 | 0.66 | TAAR1 (0.55) | CYP2D6CYP2C19TAAR1ALDH1A1CHRM2 | |
| SCHEMBL13145782 | 0.66 | TAAR1 (0.48) | CYP2D6CYP2C19TAAR1ALDH1A1CHRM2 | |
| SCHEMBL13338416 | 0.66 | ALDH1A1 (0.46) | CYP2D6CYP2C19TAAR1ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023028338-A2 | MANNOSE 6-PHOSPHATE OR ASGPR RECEPTOR BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2023-03-02 | — | — | WO | disclosed |
| WO-2022235699-A2 | POTENT ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF IMMUNOGLOBULINS AND OTHER PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |
| US-9610368-B2 | Radiolabelled glutaminyl cyclase (QC) inhibitors and uses of same | PROBIODRUG AG (DE) | 2017-04-04 | — | — | US | disclosed |