Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER2 | P43116 | 3/20 | 0.61 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.61 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.61 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2436757 | 0.90 | PTGER2 (0.59) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL3322222 | 0.87 | PTGER4 (0.50) | PTGER2PTGER4PTGDRGAAALDH1A1 | |
| SCHEMBL2440010 | 0.85 | PTGER4 (0.57) | PTGER2PTGER4PTGDRGAAHPGD | |
| SCHEMBL2438543 | 0.84 | PTGER2 (0.48) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2435130 | 0.83 | PTGER2 (0.59) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2435041 | 0.83 | PTGER2 (0.54) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2440526 | 0.83 | PTGER2 (0.54) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2435225 | 0.80 | PTGER2 (0.58) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL3321497 | 0.80 | PTGER2 (0.68) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2435180 | 0.79 | CHRM2 (0.44) | PTGER2PTGER4PTGDRHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364296-A1 | PYRROLIDINES | Pfizer Limited (GB) | 2011-09-14 | — | — | EP | claimed |
| WO-2010052625-A1 | PYRROLIDINES | PFIZER LIMITED (GB) | 2010-05-14 | — | — | WO | claimed |
| EP-2364296-A1 | PYRROLIDINES | Pfizer Limited (GB) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010052625-A1 | PYRROLIDINES | PFIZER LIMITED (GB) | 2010-05-14 | — | — | WO | disclosed |