Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 5/20 | 0.54 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 5/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2466243 | 0.82 | PLK1 (0.53) | PLK1KAT8EPHX2PPARAPPARG | |
| SCHEMBL2470089 | 0.78 | STAT3 (0.67) | PLK1KAT8 | |
| SCHEMBL6032191 | 0.78 | PLK1 (0.50) | PLK1KAT8NR1H4EPHX2PPARA | |
| SCHEMBL2470498 | 0.75 | STAT3 (0.57) | PLK1NR1H4EPHX2PPARAPPARG | |
| SCHEMBL2468230 | 0.73 | KAT8 (0.52) | PLK1KAT8PLK3TRPV1 | |
| SCHEMBL2468737 | 0.71 | PLK1 (0.50) | PLK1KAT8 | |
| SCHEMBL2468215 | 0.71 | KAT8 (0.47) | PLK1KAT8TRPV1 | |
| SCHEMBL6032331 | 0.71 | KAT8 (0.48) | PLK1KAT8PLK3TRPV1 | |
| SCHEMBL6032327 | 0.71 | KAT8 (0.48) | PLK1KAT8PLK3TRPV1 | |
| SCHEMBL26671009 | 0.70 | PLK1 (1.00) | PLK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656139-B1 | ARYL DICARBOXAMIDES | MERCK SERONO SA (CH) | 2011-10-05 | — | — | EP | claimed |