Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3563505 | 0.77 | MIF (0.43) | EPHX1ALPIPKMPTGS1XIAP | |
| SCHEMBL2466830 | 0.77 | EPHX1 (0.55) | EPHX1ALPIPKMPTGS1XIAP | |
| SCHEMBL3607845 | 0.75 | SLC1A3 (0.49) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL1462830 | 0.74 | CYP1A2 (0.44) | EPHX1ALPIPKMPTGS1XIAP | |
| SCHEMBL4888830 | 0.73 | EPHX1 (0.38) | EPHX1ALPIPKMPTGS1XIAP | |
| SCHEMBL4619739 | 0.73 | SLC1A3 (0.43) | EPHX1ALPIPKMPTGS1XIAP | |
| SCHEMBL5073587 | 0.73 | MIF (0.39) | EPHX1ALPIPKMPTGS1XIAP | |
| SCHEMBL506238 | 0.73 | LMNA (0.37) | EPHX1ALPIPKMPTGS1XIAP | |
| SCHEMBL5806034 | 0.71 | EPHX1 (0.41) | EPHX1ALPIPKMPTGS1XIAP | |
| SCHEMBL1430902 | 0.71 | MIF (0.56) | ALPIPKMPTGS1XIAPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501830-B1 | 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-10-05 | — | — | EP | claimed |