Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 18/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24729486 | 0.88 | METTL3 (0.42) | METTL3KLKB1 | |
| SCHEMBL29927404 | 0.88 | METTL3 (0.42) | METTL3KLKB1 | |
| SCHEMBL29305425 | 0.87 | METTL3 (0.46) | METTL3KLKB1 | |
| SCHEMBL29926787 | 0.87 | METTL3 (0.44) | METTL3KLKB1 | |
| SCHEMBL24729470 | 0.87 | METTL3 (0.44) | METTL3KLKB1 | |
| SCHEMBL29927129 | 0.87 | METTL3 (0.44) | METTL3KLKB1 | |
| SCHEMBL24729484 | 0.87 | METTL3 (0.44) | METTL3KLKB1 | |
| SCHEMBL24729620 | 0.87 | METTL3 (0.44) | METTL3KLKB1 | |
| SCHEMBL24729466 | 0.87 | METTL3 (0.44) | METTL3KLKB1KDM4ETP53 | |
| SCHEMBL29879114 | 0.87 | METTL3 (0.44) | METTL3KLKB1KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| WO-2022197755-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |