Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.36 |
| ▸ | JAK3 | P52333 | 8/20 | 0.36 |
| ▸ | JAK1 | P23458 | 6/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480781 | 0.96 | JAK2 (0.39) | JAK2JAK3JAK1DGAT1 | |
| SCHEMBL2376895 | 0.81 | JAK2 (0.35) | JAK2JAK3JAK1DGAT1 | |
| SCHEMBL2375797 | 0.81 | TAS1R3 (0.41) | JAK2JAK3JAK1DGAT1 | |
| SCHEMBL2375794 | 0.81 | TAS1R3 (0.41) | JAK2JAK3JAK1DGAT1 | |
| SCHEMBL2375791 | 0.81 | TAS1R3 (0.41) | JAK2JAK3JAK1DGAT1 | |
| SCHEMBL2378417 | 0.80 | TAS1R3 (0.40) | JAK2JAK3JAK1DGAT1 | |
| SCHEMBL2377260 | 0.80 | JAK2 (0.35) | JAK2JAK3JAK1 | |
| SCHEMBL2376119 | 0.80 | JAK2 (0.56) | JAK2JAK3JAK1 | |
| SCHEMBL2377753 | 0.79 | JAK2 (0.32) | JAK2JAK3JAK1DGAT1 | |
| SCHEMBL2377203 | 0.79 | JAK2 (0.35) | JAK2JAK3JAK1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373653-A1 | PYRROLOPYRAZINYL UREA KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010063634-A1 | PYRROLOPYRAZINYL UREA KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |