Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | SCN11A | Q9UI33 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 4/20 | 0.31 |
| ▸ | CNR2 | P34972 | 4/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | EBP | Q15125 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24733575 | 0.87 | SCN1A (0.42) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL23963905 | 0.77 | GBA1 (0.50) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL21254312 | 0.74 | EBP (0.41) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL30616172 | 0.73 | GBA1 (0.46) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL8237680 | 0.73 | GBA1 (0.46) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL23507432 | 0.71 | GBA1 (0.42) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL18099389 | 0.70 | GBA1 (0.50) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL18459033 | 0.69 | GBA1 (0.42) | GBA1KCNH2CYP11B2CHRM4ACHE | |
| SCHEMBL22878336 | 0.69 | GBA1 (0.46) | GBA1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL17285960 | 0.69 | GBA1 (0.46) | GBA1SCN1ASCN4ASCN7AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022249006-A1 | USE OF 1,2,4-OXADIAZOLE DERIVATIVES AS LIVER X RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2022-12-01 | — | — | WO | disclosed |