Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | SCN11A | Q9UI33 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.31 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23963905 | 0.84 | GBA1 (0.50) | GBA1CHRM4CHRM2SCN1ASCN4A | |
| SCHEMBL23507419 | 0.81 | BRD4 (0.33) | PDE9AACHE | |
| SCHEMBL23507626 | 0.80 | NCF1 (0.37) | ACHE | |
| SCHEMBL23507493 | 0.80 | GBA1 (0.43) | GBA1ACHE | |
| SCHEMBL30616172 | 0.72 | GBA1 (0.46) | GBA1CHRM4CHRM2SCN1ASCN4A | |
| SCHEMBL8237680 | 0.72 | GBA1 (0.46) | GBA1CHRM4CHRM2SCN1ASCN4A | |
| SCHEMBL24733588 | 0.71 | GBA1 (0.43) | GBA1CHRM4CHRM2SCN1ASCN4A | |
| SCHEMBL23507248 | 0.71 | GBA1 (0.40) | GBA1CHRM4CHRM2HTR4ACHE | |
| SCHEMBL18099389 | 0.69 | GBA1 (0.50) | GBA1CHRM4CHRM2SCN1ASCN4A | |
| SCHEMBL17285960 | 0.68 | GBA1 (0.46) | GBA1CHRM4CHRM2SCN1ASCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193604-B1 | SUBSTITUTED N-(PYRROLIDIN-3-YL)ISOXAZOLE-3-CARBOXAMIDE COMPOUNDS | EPIZYME INC (US) | 2021-06-16 | — | — | EP | disclosed |