Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 18/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24737595 | 0.88 | METTL3 (0.42) | METTL3KLKB1 | |
| SCHEMBL29305141 | 0.82 | KLKB1 (0.45) | METTL3KLKB1 | |
| SCHEMBL29879714 | 0.82 | KLKB1 (0.45) | METTL3KLKB1 | |
| SCHEMBL27033680 | 0.80 | KLKB1 (0.55) | KLKB1 | |
| SCHEMBL29957768 | 0.80 | KLKB1 (0.55) | KLKB1 | |
| SCHEMBL29141788 | 0.79 | METTL3 (0.43) | METTL3KLKB1 | |
| SCHEMBL27033449 | 0.77 | KLKB1 (0.38) | METTL3KLKB1 | |
| SCHEMBL29958482 | 0.76 | METTL3 (0.42) | METTL3KLKB1 | |
| SCHEMBL27033752 | 0.76 | METTL3 (0.42) | METTL3KLKB1 | |
| SCHEMBL27033679 | 0.76 | KLKB1 (0.38) | METTL3KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |