Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.37 |
| ▸ | ABL1 | P00519 | 4/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29879407 | 0.88 | METTL3 (0.44) | L3MBTL1KLKB1METTL3 | |
| SCHEMBL29303134 | 0.88 | METTL3 (0.44) | L3MBTL1KLKB1METTL3 | |
| SCHEMBL29879393 | 0.77 | KLKB1 (0.42) | KLKB1METTL3 | |
| SCHEMBL24737784 | 0.77 | KLKB1 (0.42) | KLKB1METTL3 | |
| SCHEMBL29305425 | 0.76 | METTL3 (0.46) | L3MBTL1KLKB1METTL3 | |
| SCHEMBL21355245 | 0.70 | KDM4E (0.42) | L3MBTL1ABL1KDM4ETP53METTL3 | |
| SCHEMBL21368412 | 0.69 | KLKB1 (0.44) | KDM4ETP53KLKB1METTL3 | |
| SCHEMBL29305553 | 0.69 | METTL3 (0.46) | ABL1KLKB1METTL3 | |
| SCHEMBL24737770 | 0.69 | METTL3 (0.43) | KLKB1METTL3 | |
| SCHEMBL29305492 | 0.69 | METTL3 (0.43) | KLKB1METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |