Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.47 |
| ▸ | F2 | P00734 | 3/20 | 0.47 |
| ▸ | F11 | P03951 | 11/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15790774 | 0.82 | POLB (0.40) | NOTUMKDM4EALDH1A1 | |
| SCHEMBL11117017 | 0.77 | NOTUM (0.56) | NOTUMF2KDM4EALDH1A1 | |
| SCHEMBL29757989 | 0.74 | NOTUM (0.53) | NOTUMF2KDM4EALDH1A1LMNA | |
| SCHEMBL30136136 | 0.74 | NOTUM (0.53) | NOTUMF2F11KDM4EALDH1A1 | |
| SCHEMBL29958128 | 0.74 | NOTUM (0.53) | NOTUMF2F11KDM4EALDH1A1 | |
| SCHEMBL23466554 | 0.74 | NOTUM (0.53) | NOTUMF2KDM4EALDH1A1LMNA | |
| SCHEMBL3009848 | 0.74 | NOTUM (0.53) | NOTUMF2F11KDM4EALDH1A1 | |
| SCHEMBL8177591 | 0.74 | NOTUM (0.53) | NOTUMF2F11KDM4EALDH1A1 | |
| SCHEMBL16615357 | 0.74 | NOTUM (0.53) | NOTUMF2KDM4EALDH1A1LMNA | |
| SCHEMBL478475 | 0.74 | NOTUM (0.53) | NOTUMF2F11KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |