Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14701485 | 1.00 | L3MBTL1 (0.38) | L3MBTL1HRH3KDM4EDRD2DRD3 | |
| SCHEMBL13080712 | 1.00 | L3MBTL1 (0.38) | L3MBTL1HRH3KDM4EDRD2DRD3 | |
| SCHEMBL9289101 | 0.94 | KDM4E (0.38) | L3MBTL1HRH3KDM4E | |
| SCHEMBL19121892 | 0.92 | HRH3 (0.37) | L3MBTL1HRH3KDM4E | |
| SCHEMBL19889384 | 0.83 | HRH3 (0.37) | HRH3KDM4E | |
| SCHEMBL26728551 | 0.83 | HRH3 (0.37) | HRH3KDM4E | |
| SCHEMBL14856339 | 0.81 | KDM4E (0.35) | HRH3KDM4E | |
| SCHEMBL28493524 | 0.81 | KDM4E (0.32) | HRH3KDM4E | |
| SCHEMBL14856282 | 0.81 | KDM4E (0.35) | HRH3KDM4E | |
| SCHEMBL25740962 | 0.81 | KDM4E (0.36) | HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |