Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 3/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29880256 | 0.86 | HTR2C (0.55) | HTR2CHTR2AHTR2BHSD11B1CCR2 | |
| SCHEMBL29302262 | 0.86 | HTR2C (0.55) | HTR2CHTR2AHTR2BHSD11B1CCR2 | |
| SCHEMBL301325 | 0.81 | MAOB (0.55) | HTR2CHTR2AHTR2BHSD11B1KDM1A | |
| SCHEMBL2833213 | 0.80 | MAOB (0.56) | HSD11B1CCR2KDM1AMAOBMAOA | |
| SCHEMBL29878836 | 0.79 | HTR2C (0.48) | HTR2CHTR2AHTR2BHSD11B1ALDH1A1 | |
| SCHEMBL24738866 | 0.79 | HTR2C (0.48) | HTR2CHTR2AHTR2BHSD11B1ALDH1A1 | |
| SCHEMBL11083629 | 0.78 | HSD11B1 (0.45) | HTR2CHTR2AHTR2BHSD11B1CCR2 | |
| SCHEMBL11083627 | 0.78 | HSD11B1 (0.45) | HTR2CHTR2AHTR2BHSD11B1CCR2 | |
| SCHEMBL29302947 | 0.75 | HSD11B1 (0.42) | HTR2CHTR2AHTR2BHSD11B1CCR2 | |
| SCHEMBL29879558 | 0.75 | HSD11B1 (0.42) | HTR2CHTR2AHTR2BHSD11B1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228488-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-11 | — | — | US | disclosed |
| US-20240228488-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-11 | — | — | US | disclosed |
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228488-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | KLKB1, KLK5, KLK1 | HTR2C 3558/4885HTR2A 3223/4885HTR2B 2736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.