Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 8/20 | 0.59 |
| ▸ | S1PR4 | O95977 | 7/20 | 0.59 |
| ▸ | S1PR3 | Q99500 | 7/20 | 0.59 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.59 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.59 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.59 |
| ▸ | GPR183 | P32249 | 1/20 | 0.59 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.59 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.51 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | TACR2 | P21452 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14820417 | 1.00 | S1PR1 (0.59) | S1PR1S1PR4S1PR3TNNC1S1PR5 | |
| SCHEMBL14820416 | 1.00 | S1PR1 (0.59) | S1PR1S1PR4S1PR3TNNC1S1PR5 | |
| SCHEMBL15650213 | 0.89 | S1PR1 (0.65) | S1PR1S1PR4S1PR3TNNC1S1PR5 | |
| SCHEMBL177208 | 0.82 | TNNC1 (0.68) | S1PR1S1PR4S1PR3TNNC1S1PR5 | |
| SCHEMBL7614952 | 0.80 | S1PR1 (0.79) | S1PR1S1PR4S1PR3TNNC1S1PR5 | |
| SCHEMBL23785536 | 0.77 | TNNC1 (0.70) | S1PR1S1PR4S1PR3TNNC1S1PR5 | |
| SCHEMBL7614987 | 0.77 | S1PR1 (0.85) | S1PR1S1PR4S1PR3TNNC1S1PR5 | |
| SCHEMBL7614688 | 0.77 | S1PR1 (0.85) | S1PR1S1PR4S1PR3TNNC1S1PR5 | |
| Hydrochloric Acid SCHEMBL7707997 | 0.77 | S1PR1 (0.68) | S1PR1S1PR4S1PR3TNNC1S1PR5 | |
| SCHEMBL7620859 | 0.77 | S1PR1 (0.85) | S1PR1S1PR4S1PR3TNNC1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10111841-B2 | Stabilization of alcohol intoxication-induced cardiovascular instability | UNIVERSITY OF SOUTH FLORIDA (US) | 2018-10-30 | — | — | US | disclosed |
| US-9763980-B2 | Combined chemical modification of sphingosine-1-phosphate (S1P) and CXCR4 signalling pathways for hematopoietic stem cell (HSC) mobilization and engraftment | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2017-09-19 | — | — | US | disclosed |
| US-20170020826-A1 | STABILIZATION OF ALCOHOL INTOXICATION-INDUCED CARDIOVASCULAR INSTABILITY | UNIVERSITY OF SOUTH FLORIDA (US) | 2017-01-26 | — | — | US | disclosed |
| US-20140193376-A1 | COMBINED CHEMICAL MODIFICATION OF SPHINGOSINE-1-PHOSPHATE (S1P) AND CXCR4 SIGNALLING PATHWAYS FOR HEMATOPOIETIC STEM CELL (HSC) MOBILIZATION AND ENGRAFTMENT | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2014-07-10 | — | — | US | disclosed |
| EP-2720690-A1 | COMBINED CHEMICAL MODIFICATION OF SPHINGOSINE-1-PHOSPHATE (S1P) AND CXCR4 SIGNALLING PATHWAYS FOR HEMATOPOIETIC STEM CELL (HSC) MOBILIZATION AND ENGRAFTMENT | Children's Medical Center Corporation (US) | 2014-04-23 | — | — | EP | disclosed |
| US-20130079309-A1 | Method Of Treating Acute Lung Injury Using Sphingosine 1 Phosphate Analogs Or Sphingosine 1 Phosphate Receptor Agonists | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2013-03-28 | — | — | US | disclosed |
| WO-2012174522-A1 | COMBINED CHEMICAL MODIFICATION OF SPHINGOSINE-1-PHOSPHATE (S1P) AND CXCR4 SIGNALLING PATHWAYS FOR HEMATOPOIETIC STEM CELL (HSC) MOBILIZATION AND ENGRAFTMENT | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2011109650-A1 | METHOD OF TREATING ACUTE LUNG INJURY USING SPHINGOSINE 1 PHOSPHATE ANALOGES OR SPHINGOSINE 1 PHOSPHATE RECEPTOR AGONISTS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2011-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140193376-A1 | COMBINED CHEMICAL MODIFICATION OF SPHINGOSINE-1-PHOSPHATE (S1P) AND CXCR4 SIGNALLING PATHWAYS FOR HEMATOPOIETIC STEM CELL (HSC) MOBILIZATION AND ENGRAFTMENT | S1PR1, S1PR4, S1PR3 | S1PR1 1/4885S1PR4 2/4885S1PR3 3/4885 |
| US-20130079309-A1 | Method Of Treating Acute Lung Injury Using Sphingosine 1 Phosphate Analogs Or Sphingosine 1 Phosphate Receptor Agonists | S1PR1, S1PR5, S1PR3 | S1PR1 1/4885S1PR4 6/4885S1PR3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.