SCHEMBL24740865

SCHEMBL24740865

CNC(=O)c1ccc(-c2cn3c(n2)sc2cc(C(=O)N(C)CCCN4CCCCC4)ccc23)cc1

nearest known ligand 0.64

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 8/20 0.64
▸ THRB P10828 2/20 0.62
▸ TP53 P04637 5/20 0.62
▸ POLB P06746 2/20 0.52
▸ SMN1; SMN2 Q16637 1/20 0.52
▸ LMNA P02545 3/20 0.50
▸ RXFP1 Q9HBX9 1/20 0.50
▸ SLC2A1 P11166 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30086093 1.00 MAPT (0.64) MAPTTHRBTP53POLBSMN1; SMN2
SCHEMBL24619222 0.86 MAPT (0.86) MAPTTHRBTP53POLBSMN1; SMN2
SCHEMBL29925199 0.86 MAPT (0.86) MAPTTHRBTP53POLBSMN1; SMN2
SCHEMBL30086060 0.85 MAPT (0.65) MAPTTHRBTP53LMNARXFP1
SCHEMBL24741002 0.85 MAPT (0.84) MAPTTHRBTP53POLBSMN1; SMN2
SCHEMBL30085964 0.85 MAPT (0.84) MAPTTHRBTP53POLBSMN1; SMN2
SCHEMBL24619908 0.85 MAPT (0.65) MAPTTHRBTP53LMNARXFP1
SCHEMBL24619403 0.82 MAPT (0.62) MAPTTHRBTP53POLBSMN1; SMN2
SCHEMBL30085978 0.82 MAPT (0.62) MAPTTHRBTP53POLBSMN1; SMN2
SCHEMBL24741290 0.79 LMNA (0.67) MAPTTHRBTP53POLBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024010762-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2024-01-11 — — WO disclosed
US-20220370431-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2022-11-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220370431-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER MYC, MYCBP, MYCBP2 MAPT 3215/4885THRB 2134/4885TP53 96/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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