Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 4/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2328281 | 0.84 | AVPR1A (0.49) | ESR2NR1H2 | |
| SCHEMBL3765031 | 0.84 | ESR2 (0.41) | MAPK1ESR2NR1H2DDB1CRBN | |
| SCHEMBL3762487 | 0.81 | MAPK1 (0.49) | MAPK1NAMPTESR2NR1H2DDB1 | |
| SCHEMBL2578140 | 0.78 | TACR1 (0.34) | MAPK1NAMPTESR2NR1H2SMARCA2 | |
| SCHEMBL12197348 | 0.78 | MAPK1 (0.46) | MAPK1NAMPTESR2NR1H2DDB1 | |
| SCHEMBL29676965 | 0.77 | MAPK1 (0.64) | MAPK1NAMPTESR2NR1H2DDB1 | |
| SCHEMBL5183098 | 0.77 | MAPK1 (0.64) | MAPK1NAMPTESR2NR1H2DDB1 | |
| SCHEMBL2550063 | 0.77 | NAMPT (0.40) | NAMPTESR2DDB1CRBN | |
| SCHEMBL2573980 | 0.76 | DDB1 (0.38) | MAPK1ESR2NR1H2SMARCA2SMARCA4 | |
| SCHEMBL2478651 | 0.75 | USP30 (0.37) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250157-B1 | NOVEL HETEROCYCLIC COMPOUNDS | PANACEA BIOTEC LTD (IN) | 2014-11-05 | — | — | EP | disclosed |
| EP-2370441-A1 | ARYLCYCLOHEXYLETHERS OF DIHYDROTETRAAZABENZOAZULENES FOR USE AS VASOPRESSIN VIA RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-10-05 | — | — | EP | disclosed |