Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.77 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.77 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.77 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.77 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2128085 | 0.88 | TGFBR1 (0.77) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL14344430 | 0.88 | TGFBR1 (0.80) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL29381400 | 0.87 | TGFBR1 (1.00) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL411646 | 0.87 | TGFBR1 (1.00) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL29361383 | 0.87 | TGFBR1 (1.00) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL14344351 | 0.84 | TGFBR1 (0.74) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL14344357 | 0.83 | TGFBR1 (0.72) | TGFBR1PRKD3PRKD1PRKD2MEN1 | |
| SCHEMBL2126398 | 0.79 | TGFBR1 (0.64) | TGFBR1PRKD3PRKD1PRKD2FLT1 | |
| SCHEMBL14344415 | 0.76 | TGFBR1 (0.62) | TGFBR1PRKD3PRKD1PRKD2MEN1 | |
| SCHEMBL2128905 | 0.76 | TGFBR1 (0.59) | TGFBR1PRKD3PRKD1PRKD2FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11413286-B2 | Producing astrocytes using small molecules | CITY OF HOPE (US) | 2022-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11413286-B2 | Producing astrocytes using small molecules | CHAT, GMFG, DCX | TGFBR1 3711/4885PRKD3 1516/4885PRKD1 2213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.