Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.45 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.44 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | IL1B | P01584 | 1/20 | 0.44 |
| ▸ | MAP1LC3B | Q9GZQ8 | 4/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24745075 | 0.87 | CRBN (0.48) | CRBNIKZF3BRD4DDB1IKZF1 | |
| SCHEMBL22940162 | 0.82 | CRBN (0.65) | CRBNIKZF3BRD4DDB1IKZF1 | |
| SCHEMBL21304411 | 0.80 | CRBN (0.70) | CRBNIKZF3BRD4DDB1IKZF1 | |
| SCHEMBL15711555 | 0.80 | CRBN (0.70) | CRBNIKZF3BRD4DDB1IKZF1 | |
| Hydrochloric Acid SCHEMBL1424536 | 0.79 | CRBN (0.69) | CRBNIKZF3BRD4DDB1IKZF1 | |
| SCHEMBL24745078 | 0.78 | DDB1 (0.51) | CRBNIKZF3DDB1IKZF1TNF | |
| SCHEMBL10074217 | 0.78 | CRBN (0.43) | CRBNIKZF3BRD4DDB1IKZF1 | |
| SCHEMBL24773627 | 0.76 | — | — | |
| SCHEMBL24744480 | 0.74 | IKZF2 (0.50) | CRBNIKZF3DDB1IKZF1CSNK1A1 | |
| SCHEMBL19359379 | 0.74 | CRBN (0.45) | CRBNIKZF3BRD4DDB1IKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022255888-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |
| WO-2022253713-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |