Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF2 | Q9UKS7 | 11/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 10/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.46 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.39 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24745571 | 0.87 | CRBN (0.56) | IKZF2CRBNCSNK1A1IKZF1GSPT1 | |
| SCHEMBL29547357 | 0.80 | IKZF2 (0.74) | IKZF2CRBNCSNK1A1IKZF1GSPT1 | |
| SCHEMBL19503550 | 0.80 | IKZF2 (0.74) | IKZF2CRBNCSNK1A1IKZF1GSPT1 | |
| SCHEMBL25571538 | 0.80 | IKZF2 (0.74) | IKZF2CRBNCSNK1A1IKZF1GSPT1 | |
| SCHEMBL24745076 | 0.80 | CRBN (0.52) | IKZF2CRBNIKZF1GSPT1DDB1 | |
| SCHEMBL24773806 | 0.79 | IKZF2 (0.43) | IKZF2CRBNCSNK1A1IKZF1GSPT1 | |
| SCHEMBL24774112 | 0.76 | CSNK1A1 (0.32) | IKZF2CRBNCSNK1A1 | |
| SCHEMBL26534707 | 0.75 | IKZF2 (0.41) | IKZF2CRBNIKZF1 | |
| SCHEMBL24744481 | 0.74 | CRBN (0.45) | CRBNCSNK1A1IKZF1DDB1IKZF3 | |
| SCHEMBL26537092 | 0.72 | CRBN (0.38) | IKZF2CRBNCSNK1A1IKZF1GSPT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022255888-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |
| WO-2022253713-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |