Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27178679 | 0.92 | NR1H2 (0.48) | NR1H2USP2SMN1; SMN2ACKR3CHRM2 | |
| SCHEMBL214593 | 0.84 | USP2 (0.49) | NR1H2USP2SMN1; SMN2ACKR3TLR8 | |
| SCHEMBL24746774 | 0.84 | NR1H2 (0.39) | NR1H2USP2SMN1; SMN2ACKR3TLR8 | |
| SCHEMBL14985093 | 0.83 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL24744872 | 0.83 | NR1H2 (0.38) | NR1H2EPHX2 | |
| SCHEMBL31208801 | 0.83 | NR1H2 (0.42) | NR1H2USP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL21302145 | 0.81 | NR1H2 (0.46) | NR1H2USP2SMN1; SMN2EPHX2CHRM2 | |
| SCHEMBL24744839 | 0.81 | NR1H2 (0.44) | NR1H2USP2SMN1; SMN2EPHX2CHRM2 | |
| SCHEMBL12193455 | 0.80 | USP2 (0.47) | NR1H2USP2SMN1; SMN2ACKR3TLR8 | |
| SCHEMBL29262052 | 0.80 | NR1H2 (0.39) | NR1H2USP2SMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253713-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |