Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PDE6D | O43924 | 1/20 | 0.37 |
| ▸ | PTAFR | P25105 | 1/20 | 0.37 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31090560 | 1.00 | TLR8 (0.42) | TLR8TLR7KDM4EPARP1MAPT | |
| SCHEMBL24744935 | 0.94 | KDM4E (0.41) | TLR8TLR7KDM4EPARP1MAPT | |
| SCHEMBL31090576 | 0.94 | KDM4E (0.41) | TLR8TLR7KDM4EPARP1MAPT | |
| SCHEMBL31090561 | 0.86 | SMN1; SMN2 (0.41) | KDM4EMAPTALDH1A1PTAFR | |
| SCHEMBL24744939 | 0.86 | SMN1; SMN2 (0.41) | KDM4EMAPTALDH1A1PTAFR | |
| SCHEMBL24744943 | 0.85 | KDM4E (0.39) | KDM4EMAPTALDH1A1GAAKMT2A | |
| SCHEMBL31090550 | 0.85 | KDM4E (0.39) | KDM4EMAPTALDH1A1GAAKMT2A | |
| SCHEMBL31090638 | 0.84 | MAPT (0.38) | KDM4EMAPTALDH1A1 | |
| SCHEMBL24745731 | 0.82 | KDM4E (0.42) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL24744940 | 0.82 | MAPT (0.41) | KDM4EMAPTALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253713-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |