Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PTAFR | P25105 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31090561 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EMAPTALDH1A1PKN1 | |
| SCHEMBL31090549 | 0.91 | MAPT (0.41) | KDM4EMAPTALDH1A1PKN1PKN2 | |
| SCHEMBL24744940 | 0.91 | MAPT (0.41) | KDM4EMAPTALDH1A1PKN1PKN2 | |
| SCHEMBL31090550 | 0.90 | KDM4E (0.39) | KDM4EMAPTALDH1A1PKN1PKN2 | |
| SCHEMBL24744943 | 0.90 | KDM4E (0.39) | KDM4EMAPTALDH1A1PKN1PKN2 | |
| SCHEMBL24745731 | 0.87 | KDM4E (0.42) | SMN1; SMN2KDM4EMAPTALDH1A1PKN1 | |
| SCHEMBL31090638 | 0.86 | MAPT (0.38) | KDM4EMAPTALDH1A1PKN1PKN2 | |
| SCHEMBL24744938 | 0.86 | TLR8 (0.42) | KDM4EMAPTALDH1A1PTAFR | |
| SCHEMBL31090560 | 0.86 | TLR8 (0.42) | KDM4EMAPTALDH1A1PTAFR | |
| SCHEMBL24745617 | 0.86 | MAPT (0.41) | KDM4EMAPTALDH1A1PKN1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117957218-A | Targeted protein degradation using bifunctional compounds that bind to ubiquitin ligases and target MCL-1 proteins | 凯普托尔治疗学股份有限公司 | 2024-04-30 | — | — | CN | disclosed |
| WO-2022253713-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |