Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24744934 | 0.93 | KDM4E (0.45) | KDM4EGLAALDH1A1GAAKMT2A | |
| SCHEMBL30121924 | 0.83 | KDM4E (0.42) | KDM4EGLAALDH1A1GAAKMT2A | |
| SCHEMBL24746810 | 0.83 | KDM4E (0.42) | KDM4EGLAALDH1A1GAAKMT2A | |
| SCHEMBL2382992 | 0.82 | KDM4E (0.50) | KDM4EGLAALDH1A1GAAKMT2A | |
| SCHEMBL30051772 | 0.79 | KDM4E (0.46) | KDM4EGLAALDH1A1GAAKMT2A | |
| SCHEMBL29262050 | 0.77 | KDM4E (0.42) | KDM4EGLAALDH1A1GAAKMT2A | |
| SCHEMBL30121849 | 0.77 | KDM4E (0.42) | KDM4EGLAALDH1A1GAAKMT2A | |
| SCHEMBL2382425 | 0.74 | SMN1; SMN2 (0.47) | KDM4EALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL30159238 | 0.74 | HDAC6 (0.36) | ALDH1A1SMN1; SMN2HTTLMNAHPGD | |
| SCHEMBL1714602 | 0.72 | NPC1 (0.52) | KDM4EGLAALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253713-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |