Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 12/20 | 0.46 |
| ▸ | JAK2 | O60674 | 9/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29891257 | 1.00 | TYK2 (0.46) | TYK2JAK2JAK1JAK3AURKA | |
| SCHEMBL24745848 | 0.85 | ZAP70 (0.50) | TYK2JAK2JAK1JAK3ZAP70 | |
| SCHEMBL24746089 | 0.84 | TYK2 (0.52) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL24745795 | 0.82 | TYK2 (0.41) | TYK2AURKAZAP70 | |
| SCHEMBL24746092 | 0.79 | TYK2 (0.51) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL30316492 | 0.79 | TYK2 (0.51) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29891348 | 0.71 | TYK2 (0.42) | TYK2JAK2JAK1JAK3ZAP70 | |
| SCHEMBL17054845 | 0.69 | TYK2 (0.80) | TYK2JAK2 | |
| SCHEMBL24747221 | 0.69 | TYK2 (0.76) | TYK2JAK2JAK1JAK3AURKA | |
| SCHEMBL1058726 | 0.68 | ZAP70 (0.59) | JAK2ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117120090-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |