Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 1/20 | 0.76 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 12/20 | 0.38 |
| ▸ | AURKA | O14965 | 4/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.38 |
| ▸ | PAK4 | O96013 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | LTK | P29376 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.38 |
| ▸ | CLK2 | P49760 | 3/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.38 |
| ▸ | MST1R | Q04912 | 3/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24747210 | 0.81 | TYK2 (0.49) | TYK2ZAP70JAK2AURKADAPK3 | |
| SCHEMBL30316224 | 0.81 | TYK2 (0.49) | TYK2ZAP70JAK2AURKADAPK3 | |
| SCHEMBL24745795 | 0.73 | TYK2 (0.41) | TYK2ZAP70AURKAKDRMAP4K4 | |
| SCHEMBL24745848 | 0.72 | ZAP70 (0.50) | TYK2ZAP70JAK2JAK3JAK1 | |
| SCHEMBL12928940 | 0.72 | ZAP70 (0.61) | TYK2ZAP70JAK2AURKADAPK3 | |
| SCHEMBL30316492 | 0.71 | TYK2 (0.51) | TYK2JAK2JAK3JAK1 | |
| SCHEMBL24746092 | 0.71 | TYK2 (0.51) | TYK2JAK2JAK3JAK1 | |
| SCHEMBL30316447 | 0.70 | TYK2 (0.44) | TYK2JAK2JAK3JAK1CYP17A1 | |
| SCHEMBL24746286 | 0.70 | TYK2 (0.44) | TYK2JAK2JAK3JAK1CYP17A1 | |
| SCHEMBL24745797 | 0.69 | TYK2 (0.46) | TYK2ZAP70JAK2AURKAJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4291235-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2023-12-20 | — | — | EP | disclosed |
| US-20230096641-A1 | HPK1 ANTAGONISTS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2023-03-30 | — | — | US | disclosed |
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230096641-A1 | HPK1 ANTAGONISTS AND USES THEREOF | PDXK, HIPK1, PCK1 | TYK2 958/4885ZAP70 1479/4885JAK2 2783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.