Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCND2 | P30279 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 6/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30316567 | 0.81 | MTOR (0.44) | CHRNB2CHRNA4MTORPIK3CA | |
| SCHEMBL17108491 | 0.81 | MTOR (0.44) | CHRNB2CHRNA4MTORPIK3CA | |
| SCHEMBL30315969 | 0.81 | MTOR (0.44) | CHRNB2CHRNA4MTORPIK3CA | |
| SCHEMBL17108489 | 0.81 | MTOR (0.44) | CHRNB2CHRNA4MTORPIK3CA | |
| SCHEMBL24562764 | 0.81 | CHRNB2 (0.41) | CHRNB2CHRNA4ELANECHRNB1CHRNB4 | |
| SCHEMBL23103865 | 0.78 | PIK3C3 (0.46) | CHRNB2CHRNA4MTORPIK3CA | |
| SCHEMBL21256946 | 0.76 | NSD2 (0.39) | ELANENSD2G6PDCCR6MTOR | |
| SCHEMBL25932737 | 0.76 | NSD2 (0.39) | ELANENSD2G6PDCCR6MTOR | |
| SCHEMBL10144219 | 0.76 | NSD2 (0.39) | ELANENSD2G6PDCCR6MTOR | |
| SCHEMBL17055164 | 0.75 | MAPT (0.59) | CHRNB2CHRNA4CDK4CCND1CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |