Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 17/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29891142 | 1.00 | TYK2 (0.47) | TYK2MAP4K1LRRK2CDK4CCND1 | |
| SCHEMBL24747220 | 0.88 | TYK2 (0.49) | TYK2MAP4K1LRRK2CDK4CCND1 | |
| SCHEMBL30316075 | 0.88 | TYK2 (0.49) | TYK2MAP4K1LRRK2CDK4CCND1 | |
| SCHEMBL24746267 | 0.87 | TYK2 (0.46) | TYK2MAP4K1LRRK2CDK4CCND1 | |
| SCHEMBL24746075 | 0.87 | TYK2 (0.46) | TYK2MAP4K1LRRK2CDK4CCND1 | |
| SCHEMBL29891033 | 0.87 | SYK (0.43) | TYK2MAP4K1CDK4 | |
| SCHEMBL24745820 | 0.87 | TYK2 (0.46) | TYK2MAP4K1LRRK2CDK4CCND1 | |
| SCHEMBL24746077 | 0.87 | TYK2 (0.46) | TYK2MAP4K1LRRK2CDK4CCND1 | |
| SCHEMBL24745882 | 0.87 | SYK (0.43) | TYK2MAP4K1CDK4 | |
| SCHEMBL30316305 | 0.87 | TYK2 (0.46) | TYK2MAP4K1LRRK2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117120090-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |