Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.47 |
| ▸ | CDK4 | P11802 | 7/20 | 0.45 |
| ▸ | CCND1 | P24385 | 7/20 | 0.45 |
| ▸ | CCND3 | P30281 | 7/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 7/20 | 0.44 |
| ▸ | CDK2 | P24941 | 6/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.44 |
| ▸ | CDK9 | P50750 | 5/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CCNH | P51946 | 1/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | CCNK | O75909 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30316225 | 1.00 | MAP4K1 (0.47) | MAP4K1CDK4CCND1CCND3CDK6 | |
| SCHEMBL24746072 | 0.91 | CDK4 (0.45) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL30316534 | 0.91 | CDK4 (0.45) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL30316347 | 0.90 | SYK (0.46) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL24746073 | 0.90 | SYK (0.46) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL24747223 | 0.89 | TYK2 (0.46) | MAP4K1CDK4CCND1CCND3 | |
| SCHEMBL30316297 | 0.89 | TYK2 (0.46) | MAP4K1CDK4CCND1CCND3 | |
| SCHEMBL24746100 | 0.83 | TYK2 (0.45) | MAP4K1CDK4CCND1CDK6CDK2 | |
| SCHEMBL29892159 | 0.83 | TYK2 (0.45) | MAP4K1CDK4CCND1CDK6CDK2 | |
| SCHEMBL24746098 | 0.83 | MAP4K1 (0.43) | MAP4K1CDK4CCND1CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |