Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 8/20 | 0.44 |
| ▸ | TYK2 | P29597 | 6/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 2/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24746073 | 1.00 | SYK (0.46) | SYKZAP70TYK2CDK4CCND1 | |
| SCHEMBL30316225 | 0.90 | MAP4K1 (0.47) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL30316534 | 0.90 | CDK4 (0.45) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL24745833 | 0.90 | MAP4K1 (0.47) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL24746072 | 0.90 | CDK4 (0.45) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL24747223 | 0.88 | TYK2 (0.46) | TYK2CDK4CCND1CCND3 | |
| SCHEMBL30316297 | 0.88 | TYK2 (0.46) | TYK2CDK4CCND1CCND3 | |
| SCHEMBL24746100 | 0.82 | TYK2 (0.45) | TYK2CDK4CCND1CDK6CCNA2 | |
| SCHEMBL29892159 | 0.82 | TYK2 (0.45) | TYK2CDK4CCND1CDK6CCNA2 | |
| SCHEMBL24747211 | 0.79 | CDK4 (0.44) | TYK2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230096641-A1 | HPK1 ANTAGONISTS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2023-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230096641-A1 | HPK1 ANTAGONISTS AND USES THEREOF | PDXK, HIPK1, PCK1 | SYK 4559/4885ZAP70 1479/4885TYK2 958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.