Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24515305 | 0.94 | KDM4E (0.41) | ALDH1A1KDM4EHPGDHSD17B10LCK | |
| SCHEMBL29891154 | 0.88 | GAA (0.40) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL3515967 | 0.88 | GAA (0.40) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL24746071 | 0.85 | EGFR (0.33) | EGFRCYP3A4 | |
| SCHEMBL26918687 | 0.85 | ALDH1A1 (0.36) | ALDH1A1KDM4EHPGD | |
| SCHEMBL25641838 | 0.83 | CA9 (0.39) | ALDH1A1KDM4EHSD17B10LMNAMAPK1 | |
| SCHEMBL25344076 | 0.82 | KDM4E (0.32) | ALDH1A1KDM4EHPGDHSD17B10GPR35 | |
| SCHEMBL31024683 | 0.82 | KDM4E (0.32) | ALDH1A1KDM4EHPGDHSD17B10GPR35 | |
| SCHEMBL31537484 | 0.82 | GAA (0.40) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL23213804 | 0.81 | DHODH (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117120090-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |