Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | XDH | P47989 | 2/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31306166 | 0.89 | CA12 (0.38) | SOS1LMNATSHRL3MBTL1CA12 | |
| SCHEMBL31394743 | 0.81 | SOS1 (0.51) | SOS1LMNATSHRNPSR1NOTUM | |
| SCHEMBL34465654 | 0.81 | KDM4E (0.42) | LMNAKDM4EALDH1A1POLBGAA | |
| SCHEMBL22802075 | 0.81 | CA12 (0.42) | LMNATSHRL3MBTL1CA12CA1 | |
| SCHEMBL21585768 | 0.81 | SOS1 (0.46) | SOS1LMNATSHRNPSR1NOTUM | |
| SCHEMBL18360182 | 0.80 | KEAP1 (0.37) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1044961 | 0.80 | SOS1 (0.46) | SOS1LMNATSHRNPSR1NOTUM | |
| SCHEMBL31432736 | 0.79 | SOS1 (0.39) | SOS1LMNATSHRNPSR1NOTUM | |
| SCHEMBL10290728 | 0.78 | CYP3A4 (0.38) | SOS1LMNATSHRL3MBTL1CA12 | |
| SCHEMBL31394733 | 0.77 | SOS1 (0.36) | SOS1LMNATSHRNPSR1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117120090-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |