Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30316447 | 1.00 | TYK2 (0.44) | TYK2JAK2JAK1JAK3CDK8 | |
| SCHEMBL24747210 | 0.87 | TYK2 (0.49) | TYK2JAK2JAK1JAK3CDK8 | |
| SCHEMBL30316224 | 0.87 | TYK2 (0.49) | TYK2JAK2JAK1JAK3CDK8 | |
| SCHEMBL30316114 | 0.78 | BRAF (0.35) | TYK2JAK2JAK1 | |
| SCHEMBL24746066 | 0.78 | BRAF (0.35) | TYK2JAK2JAK1 | |
| SCHEMBL24747223 | 0.75 | TYK2 (0.46) | TYK2 | |
| SCHEMBL30316297 | 0.75 | TYK2 (0.46) | TYK2 | |
| SCHEMBL24745833 | 0.74 | MAP4K1 (0.47) | — | |
| SCHEMBL24746072 | 0.74 | CDK4 (0.45) | — | |
| SCHEMBL30316534 | 0.74 | CDK4 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |