Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 20/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 6/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2472342 | 0.90 | AVPR1A (0.33) | AVPR1A | |
| Hydrochloric Acid SCHEMBL2473468 | 0.90 | OGA (0.32) | — | |
| SCHEMBL2472708 | 0.89 | CYP11B2 (0.33) | — | |
| Hydrochloric Acid SCHEMBL2472336 | 0.88 | — | — | |
| SCHEMBL2471322 | 0.88 | AVPR1A (0.33) | AVPR1AKCNH2AVPR2OXTR | |
| Hydrochloric Acid SCHEMBL2472345 | 0.86 | — | — | |
| SCHEMBL2469112 | 0.86 | HCRTR1 (0.33) | — | |
| Hydrochloric Acid SCHEMBL2475013 | 0.86 | IP6K1 (0.33) | AVPR1AKCNH2AVPR2OXTR | |
| SCHEMBL2469536 | 0.86 | AVPR1A (0.36) | AVPR1A | |
| SCHEMBL14832404 | 0.86 | AVPR1A (0.41) | AVPR1AKCNH2AVPR2OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3035939-A1 | V1A ANTAGONISTS TO TREAT PHASE SHIFT SLEEP DISORDERS | F. Hoffmann-La Roche AG (CH) | 2016-06-29 | — | — | EP | claimed |
| WO-2015024819-A1 | V1A ANTAGONISTS TO TREAT PHASE SHIFT SLEEP DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-02-26 | — | — | WO | claimed |
| EP-3035939-A1 | V1A ANTAGONISTS TO TREAT PHASE SHIFT SLEEP DISORDERS | F. Hoffmann-La Roche AG (CH) | 2016-06-29 | — | — | EP | disclosed |
| WO-2015024819-A1 | V1A ANTAGONISTS TO TREAT PHASE SHIFT SLEEP DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-02-26 | — | — | WO | disclosed |
| EP-2370441-A1 | ARYLCYCLOHEXYLETHERS OF DIHYDROTETRAAZABENZOAZULENES FOR USE AS VASOPRESSIN VIA RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010060836-A1 | ARYLCYCLOHEXYLETHERS OF DIHYDROTETRAAZABENZOAZULENES FOR USE AS VASOPRESSIN VIA RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-03 | — | — | WO | disclosed |